Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose
نویسندگان
چکیده
منابع مشابه
Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose.
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by ...
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ژورنال
عنوان ژورنال: Science and Technology of Advanced Materials
سال: 2008
ISSN: 1468-6996,1878-5514
DOI: 10.1088/1468-6996/9/2/024407